Set against a backdrop of Mpumalanga's magnificent Malelane Mountains, the Mthethomusha Game reserve covers an area of eight thousand hectares of unspoilt nature, and is bordered by the south western reaches of the renowned Kruger National Park. Mthethomusha Game Reserve was established through an innovative joint initiative between the Tribal Authority of the Mphakeni tribe, and the management of the KaNgwane Parks Corporation. The Mthethomusha game ereserve is characterised by its prominent granite outcrops and crags, and also houses three distinct varieties of woodland vegetation, which support a wide variety of wildlife species which include klipspringer, both common large-spotted genet and white-tailed mongoose, kudu, giraffe, zebra, sable and nyala, packs of nomadic African wild dog, and the sought after "Big Five".

Mthethomusha Game Park offers visitors a number of exciting morning and evening game drives, accompanied by an experienced ranger, and conducted in open safari vehicles, taking them through the reserve and into the neighbouring Kruger National Park. Night game drives provide visitors with the magical opportunity to witness the splendour and wonder of the usually unseen nocturnal world. Guests are spoilt with views of the elusive Leopard, Genet and Civet.

An alternative to the guided game drives, are a number of informative bush walks through the reserve, led by trained rangers. These interesting routes provide excellent opportunities for visitors to explore the rugged reserve, and learn more about the indigenous fauna and flora species found there. The reserve also displays an abundance of over two hundred and fifty various San rock art sites for which the region is famous, and provide guests with interesting insights into the culture and lifestyles of the early inhabitants of the area. Well informed rangers will accompany guests on guided walks to the sites, which display various examples of San rock art, estimated to be roughly 1,500 years old.

The area which surrounds the Mthethomusha Game Reserve displays a rich cultural history, which guests can explore while paying a visit to one of the local Swazi villages. Guests can take the opportunity to socialize with the community, learn about their customs, experience the traditional Swazi lifestyle, and meet an authentic sangoma (African medicine man) which the Swazi people regard highly.