Mkuze Falls Private Game Reserve lies situated in the heart of KwaZulu Natal's historic Zululand region between Kruger National Park and the Zululand Coast. Mkuze Falls is one of only two private game reserves in the vicinity where visitors can view Africa's Big Five (lion, leopard, buffalo, rhino, and elephant).

The reserve takes its name from the waterfall in front of the main camp and covers an area of approximately 10,000 hectares. A number of unique ecosystems are displayed, and these include riverine, wetland, lowveld bushveld and montane grassland. As a result of the diversity of these habitats, a large variety of bird and animal species are also present in the reserve.

Mkuze Falls Private Game Reserve is home to the Big Five and a wide and interesting variety of other species which include cheetah, hippo, warthog, crocodile, spotted hyena, giraffe, wildebeest and zebra. Numerous species of antelope are also present in the reserve, and one of which, the elusive Nyala occurs in greater numbers in this region than anywhere else in the world. Game drives take place early morning and late afternoon, and are conducted by experienced and knowledgeable game rangers and nature guides. Only a limited number of vehicles are allowed to travel through the bush at any one time, allowing for less distractions, and a memorable experience.

For bird watching enthusiasts, Mkuze Falls Private Game Reserve provide a number of ideal locations like Mkuze Falls and its wetlands, from which to view many of the 400 recorded species of the region. A variety of special species to be found in the reserve include Natal Francolin, Bronze-winged Courser, Bearded Woodpecker, Red-billed Oxpecker, Scarlet-chested Sunbird and Red-headed Weaver. Others include Narina Trogon, Rudd's Apalis, Gorgeous Bush Shrike, African Green Pigeon, Purple-crested Turaco, Crested Guineafowl, African Finfoot and Mountain Wagtail.The Mkuze Falls Private Game Reserve is also home to a wide variety of raptors such as African Hawk, Martial, African Crowned and Tawny Eagles, Bateleur, Shikra, White-backed Vulture and African Goshawk.